The Untargeted Metabolomics Laboratory provides untargeted profiles of a significant number of metabolites in a variety of tissues, serum, plasma and cultured cells using a highly automated workflow.
The Untargeted Metabolomics platform is based on four interwoven and fully integrated aspects:
- Hardware: Because of its high mass resolution and mass accuracy, our platforms are based on HPLC/Q-TOF technology. The current generation of mass specs and software are intensely powerful, but NMR, FTIR, and other systems are available when mass spectrometry is not sufficient.
- Informatics: The science of Metabolomics is driven at least as much the informatics infrastructure as by the actual hardware platform. This begins with a LIMS system capable of tracking samples, the process through data acquisition and analysis, to the final report. A separate set of tools is available for quality control, initial data analysis and report generation.
- Robotics: Humans are too good at thinking and being creative to do the repetitive, mundane, error prone tasks involved in most sample handling. Automating processes wherever possible reduces error and enhances data quality.
- Standards-based QA/QC: The use of standards to monitor all aspects of the sample preparation and analytics assures a continuously improved process in which the level of error is always known. This allows better experiment design, which yields better quality information from fewer samples.
When you're ready to proceed, please follow the steps to submit a project service request here.
Please contact the Managing Director, Maureen Kachman, if you have questions not answered here, or to discuss details.